Software⏱️ 4 min read📅 2026-06-15

How to Fix: Windows exe program work in safe mode but error in normal (access, permissions error)

Windows exe program access permissions error in normal mode but works in safe mode.

Quick Answer: Try running the program as administrator or using a different user account to see if it resolves the issue.

📋 Table of Contents

  1. 🛑 Root Causes of the Error
  2. 🔧 Proven Troubleshooting Steps
  3. 💡 Conclusion

The error 'Windows cannot access the specified device, path, or file. You may not have the appropriate permissions to access the item.' occurs when the VMS.exe program is unable to run due to a lack of access permissions, despite working in safe mode. This issue affects users who have installed the VMS program on their Windows 10 Pro x64 system and are experiencing difficulties running it normally.

This error can be frustrating for users as they may not know why the program is not working or how to resolve the issue. In this guide, we will provide step-by-step instructions to help troubleshoot and potentially fix the access permissions error.

🛑 Root Causes of the Error

  • The primary reason for this error is that the VMS.exe program requires elevated privileges to run, which may be denied due to security settings or file system restrictions. This can also be caused by conflicting system files or registry entries that interfere with the program's execution.
  • Another possible cause of this error is a misconfigured Windows Defender setting, which may block the VMS.exe program from running even when it has been added as an exception.

🔧 Proven Troubleshooting Steps

Running VMS.exe in Elevated Mode

  1. Step 1: To run VMS.exe in elevated mode, right-click on the shortcut and select 'Run as administrator'. This will allow the program to execute with elevated privileges, bypassing any access permission errors.
  2. Step 2: Alternatively, you can also use the Task Manager to open the VMS.exe process in elevated mode. Press Ctrl+Shift+Esc to open the Task Manager, then right-click on the VMS.exe process and select 'Run as administrator'.
  3. Step 3: If running in elevated mode does not resolve the issue, proceed to method 2.

Disabling Windows Defender and Checking File System Permissions

  1. Step 1: To disable Windows Defender for a short period, press the Windows key + R to open the Run dialog box, type 'msconfig' and press Enter. In the System Configuration window, navigate to the 'Startup' tab and uncheck the box next to 'Windows Defender'. Click 'Apply' and then 'OK' to save changes.
  2. Step 2: Next, navigate to the file system location where VMS.exe is installed (usually in the Program Files or ProgramData directory). Right-click on the folder and select 'Properties', then click on the 'Security' tab. Ensure that the user account under which VMS.exe is running has read and execute permissions for all files and folders within the directory.
  3. Step 3: If you have already checked file system permissions, proceed to the next step.

💡 Conclusion

To troubleshoot and potentially fix the access permissions error, try running VMS.exe in elevated mode or disabling Windows Defender and checking file system permissions. If neither of these methods resolve the issue, further troubleshooting may be necessary, such as checking for conflicting system files or registry entries.

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